Fatty acids are attractive for biomedical industry, as they occur in nature, are processed and are hydrophobic. Thus, they retain an encapsulated drug for longer periods of time. The introduction of fatty acids in the polyesters or polyanhydrides presents some difficulties, since most natural fatty acids have only one carboxylic acid group and therefore can only be used as end of chain. However, this limitation can be overcome by using Two-functional natural fatty acids such as ricinoleic acid or bile acids, as well as the method of chemical functionalization of the fatty acids (eg, dimerization through their double bonds). Jain Group focused its review on the implementation of ricinoleic acid, which is a natural acid C18, which is produced from the hydrolysis of castor oil, a double bond C9 with cis-configuration and the hydroxyl functionality C12. It is embedded in polyester by condensation polymerization of the blocked poly (sebatsionovoy acid) having anhydride end groups. It was recently revealed that ricinoleic acid may be to produce a series of tsiklizirovana lactones, which can be copolymerized oligomerizirovat or standard methods of polymerization with ring opening, including the use of catalysts such as those described in the review of payer.
These copolymers ricinoleic acid are destroyed in natural conditions, failure occurs within a couple of weeks in vitro physiological conditions. Polymers well suited for drug delivery, since the destruction they release a model of potential drugs (cisplatin). 4 Carbon dioxide as a raw material carbon dioxide is an interesting synthetic raw materials, as it widely distributed, inexpensive, non-combustible and produces as much waste chemical processes.